武汉大学药学院王连荣研究组
City and Nature Symbiosis Green and World Peer

当前位置:

1. Xiaolin Xiong, Geng Wu, Yue Wei, Liqiong Liu, Yubing Zhang, Rui Su, Xianyue Jiang, Mengxue Li, Haiyan Gao, Xihao Tian, Yizhou Zhang, Li Hu, Si Chen, You Tang, Susu Jiang, Ruolin Huang, Zhiqiang Li, Yunfu Wang, Zixin Deng, Jiawei Wang, Peter C. Dedon, Shi Chen, Lianrong Wang*. SspABCD-SspE is a phosphorothioation-sensing bacterial defense system with broad antiphage activities, Nature Microbiology, 2020, July, 5: 917-928. DOI: 10.1038/s41564-020-0700-6.  

2. Xiaolin Wu#, Bo Cao# , Patricia Aquino, Tsu-Pei Chiu, Chao Chen, Susu Jiang , Zixin Deng, Shi Chen , Remo Rohs, Lianrong Wang*, James E Galagan*, Peter C Dedon*. Epigenetic Competition Reveals Density-Dependent Regulation and Target Site Plasticity of Phosphorothioate Epigenetics in Bacteria. Proc Natl Acad Sci U S A. 2020, June, 117 (25):14322-14330. DOI: 10.1073/pnas.2002933117.

3. Cao B , Chen C , DeMott M , Cheng Q , Clark T, Xiong X, Zheng X, Butty V , Levine S, Yuan G, Boitano M, Luong K, Song Y, Deng Z, Zhou X, Turner S, Korlach K, You D*, Wang L*, Chen S*, Dedon P. Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences. Nature Communications. 2014, 5:3951. 

4. Yue Wei, Qinqin Huang, Xihao Tian, Mingmin Zhang, Junkai He, Xingxiang Chen, Chao Chen, Zixin Deng, Zhiqiang Li, Shi Chen, and Lianrong Wang*, Single-molecule optical mapping of the distribution of DNA phosphorothioate epigenetics. Nucleic Acids Research, 2021, Doi: 10.1093/nar/gkab169.

5. Ming-Yu Wu, Meijia Gu, Jong-Kai Leung, Xinmei Li, Yuncong Yuan, Chao Shen, Lianrong Wang*, Engui Zhao*, Sijie Chen*. A Membrane-Targeting Photosensitizer with Aggregation-Induced Emission Characteristics for Highly Efficient Photodynamic Combat of Human Coronaviruses. Small, 2021, June, https://doi.org/10.1002/smll.202101770.

6. Shiwei Wang, Mengping Wan, Ruolin Huang,a Yujing Zhang, Yuqing Xie, YueWei, Mustafa Ahmad, Dan Wu, Yue Hong, Zixin Deng, Shi Chen, Zhiqiang Li, Lianrong Wang*. SspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System. mBio, 2021, 12(2) e00613-21, DOI:10.1128/mBio. 00613-21.

7. Cheng Zhang, Pengqing Nie, Chunliu Zhou, Yue Hu, Suling Duan, Meijia Gu, Dongxu Jiang, YunfuWang. Zixin Deng, Jincao Chen, Shi Chen and Lianrong Wang*. Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner. Cell Death and Disease, 2021 12:209. Doi.org/10.1038/s41419-021-03484-3.

8. Liqiong Liu#, Susu Jiang#, Mai Xing, Chao Chen, Chongde Lai, Na Li, Guangfeng Liu, Dan Wu, Haiyan Gao, Liang Hong, Pan Wu, Shi Chen, Zixin Deng, Geng Wu,* Lianrong Wang*. Structure of a L-cysteine desulfurase from a Ssp DNA phosphorothioation system in Vibrio cyclitrophicus. mBio, 2020, 11(2), DOI:10.1128/mBio.00488-20.

9. Nie P, Li Z, Wang Y, Zhang Y, Zhao M, Luo J, Du S, Deng Z, Chen J, Wang Y, Chen S, Wang L*. Gut microbiome interventions in human health and diseases. Medicinal Research Reviews, 2019 Apr 17. doi: 10.1002/med.21584. 

10. Li Y, Liu J, Wang Y, Chan H, Wang L*, Chan W*. Mass Spectrometric and Spectrophotometric Analyses Reveal an Alternative Structure and a New Formation Mechanism for Melanin. Analytical Chemistry, 2015, 87, 7958−7963.

11. Wang L, Jiang S, Chen C, He W, Wu X, Wang F, Tong T, Zou X, Li Z, Luo J, Deng Z, Chen S. Synthetic genomes: from DNA synthesis to genome design. Angew Chem Int Ed., 2018, 57: 2~11. 

12. Wang L, Jiang S, Deng Z, Dedon P, Chen S. DNA phosphorothioate modification – a new multi- functional epigenetic system in bacteria. FEMS Microbiology Reviews, 2019, 43(2), 109–122. https://doi.org/10.1093/femsre/fuy036

13. Chen C#, Wang L#, Chen S, Wu X, Gu M, Chen X, Jiang S, Wang Y, Deng Z, Dedon P, Chen S. Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes. Proc Natl Acad Sci U S A, 2017, doi: 10.1073/pnas.1702450114. 

14. Wang L#, Chen S#, Xu T, Taghizadeh K, Wishnok JS, Zhou X, Deng Z, Dedon PC. Phosphorothioation of DNA in bacteria by dnd genes. Nature Chemical Biology. 2007, 3(11):709-10.

15. Wang L, Chen S, Vergin KL, Giovannoni Sj. Chan SW, Demott MS, Taghizadeh K, Cordero OX, Cutler M, Timberlake S, Alm EJ, Polz MF, Pinhassi J, Deng Z, Dedon PC. DNA phosphorothioation is widespread and quantized in bacterial genomes. Proc Natl Acad Sci USA. 2011, 108(7):2963-8.

16. Tong T#, Chen S#, Wang L#, Tang Y#, Ryu JY, Jiang S, Wu X, Chao Chen C, Luo J, Deng Z, Li Z, Lee SY*, Shi Chen*. Occurrence, evolution, and functions of DNA phosphorothioate epigenetics in bacteria, Proc Natl Acad Sci U S A, 2018, doi:10.1073/pnas.1721916115. 

17. Gu M, Zixuan Zeng, Xing M, Xiong Y, Deng Z, Chen S, Wang L*. The Biological Applications of Two Aggregation-induced Emission Luminogens. Biotechnology Journal, 2019, 14, 1900212.

18. Wang F#, Wang L#, Zou X., Duan S., Li Z., Deng Z., Luo J., Lee S. Y.*, Chen S*. Advances in CRISPR-Cas systems for RNA targeting, tracking and editing. Biotechnology Advances, 2019, doi.org/10.1016/j.biotechadv.2019.03.016.

19. Wu S#, Wang L#, Gan R, Tong T, Bian H, Li Z, Du S, Deng Z, Chen S. Signature arsenic detoxification pathways in Halomonas sp. GFAJ-1, mBio, 2018, May 1; 9 (3): e00515-18. doi: 10.1128/mBio.00515-18.

20. Zou X#, Wang L#, Li Z, Luo J, Wang Y, Deng Z, Du S, Chen S. Genome engineering and modification toward synthetic biology for the production of antibiotics. Medicinal Research Reviews, 2017, online March 15th. 

21. Wang L, Chen S, Xiao X, Huang X, You D, Zhou X, Deng Z. arsRBOCT arsenic resistance system encoded by linear plasmid pHZ227 in Streptomyces sp. Strain FR-008. Applied and Environmental Microbiology. 2006, 72(5):3738-42.

22. Wang L., Chen S., Deng Z. Phosphorothioation: an unusual post-replicative modification on the DNA backbone. Book Chapter. DNA replication. 2011.