武汉大学药学院王连荣研究组
City and Nature Symbiosis Green and World Peer

当前位置:

 (1) Xiaolin Xiong, Geng Wu, Yue Wei, Liqiong Liu, Yubing Zhang, Rui Su, Xianyue Jiang, Mengxue Li, Haiyan Gao, Xihao Tian, Yizhou Zhang, Li Hu, Si Chen, You Tang, Susu Jiang, Ruolin Huang, Zhiqiang Li, Yunfu Wang, Zixin Deng, Jiawei Wang, Peter C. Dedon, Shi Chen, Lianrong Wang*. SspABCD-SspE is a phosphorothioation-sensing bacterial defense system with broad antiphage activities, Nature Microbiology, 2020, July, 5: 917-928. DOI: 10.1038/s41564-020-0700-6.  文章链接: https://www.ncbi.nlm.nih.gov/pubmed/32251370

 (2)  Xiaolin Wu#Bo Cao# Patricia AquinoTsu-Pei ChiuChao ChenSusu Jiang Zixin DengShi Chen Remo RohsLianrong Wang*James E Galagan*Peter C Dedon*. Epigenetic Competition Reveals Density-Dependent Regulation and Target Site Plasticity of Phosphorothioate Epigenetics in Bacteria. Proc Natl Acad Sci U S A. 2020, June, 117 (25):14322-14330.  doi: 10.1073/pnas.2002933117.

 (3) Bo Cao#, Chao Chen#, Michael S. DeMott#, Qiuxiang Cheng, Tyson A. Clark, Xiaolin Xiong, Xiaoqing Zheng, Vincent Butty, Stuart S. Levine, George Yuan, Matthew Boitano, Khai Luong, Yi Song, Xiufen Zhou, Zixin Deng, Stephen W. Turner, Jonas Korlach, Delin You*, Lianrong Wang*, Shi Chen*, Peter C. Dedon. Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences. Nature Communications. 2014, 5: 3951.

(4)  Liqiong Liu#, Susu Jiang#, Mai Xing, Chao Chen, Chongde Lai, Na Li, Guangfeng Liu, Dan Wu, Haiyan Gao, Liang Hong, Pan Wu, Shi Chen, Zixin Deng, Geng Wu,* Lianrong Wang*. Structure of a L-cysteine desulfurase from a Ssp DNA phosphorothioation system in Vibrio cyclitrophicus. mBio, 2020, 11(2), DOI:10.1128/mBio.00488-20.

(5)     Pengqing Nie#, Zhiqiang Li#, Yimeng Wang, Yubing Zhang, Mengna Zhao, Jie Luo, Shiming Du, Zixin Deng, Jincao Chen, Yunfu Wang, Shi Chen, Lianrong Wang*. Gut microbiome interventions in human health and diseases. Medicinal Research Reviews, 2019 Apr 17. doi: 10.1002/med.21584

(6)     Yuanjiao Li, Jingjing Liu, Yajie Wang, Ho Wai Chan, Lianrong Wang*, Wan Chan*. Mass Spectrometric and Spectrophotometric Analyses Reveal an Alternative Structure and a New Formation Mechanism for Melanin. Analytical Chemistry, 2015, 87, 7958−7963.

(7)     Gu M, Zixuan Zeng, Xing M, Xiong Y, Deng Z, Chen S, Wang L*. The Biological Applications of Two Aggregation-induced Emission Luminogens. Biotechnology Journal, 2019, 14, 1900212.

(8)     Lianrong Wang, Shi Chen*, Kevin L. Vergin, Stephen J. Giovannoni, Simon W. Chan, Michael S. DeMott, Koli Taghizadehe, Otto X. Cordero, Michael Cutler, Sonia Timberlake, Eric J. Alm, Martin F. Polz, Jarone Pinhassi, Zixin Deng, Peter C. Dedon*. DNA phosphorothioation is widespread and quantized in bacterial genomes. Proc Natl Acad Sci USA. 2011; 108(7):2963-8.

(9)     Lianrong Wang#, Shi Chen#, Tiegang Xu, Koli Taghizadeh, John S Wishnok, Xiufen Zhou, Delin You, Zixin Deng*, Peter C Dedon*. Phosphorothioation of DNA in bacteria by dnd genes. Nature Chemical Biology. 2007;3(11):709-10.

(10)  Lianrong Wang, Susu Jiang, Chao Chen, Wei He, Xiaolin Wu, Fei Wang, Tong Tong, Xuan Zou, Zhiqiang Li, Jie Luo, Zixin Deng, and Shi Chen*. Synthetic Genomics: From DNA Synthesis to Genome Design, Angew Chemie Int Ed, 2018, Feb, 57(7): 1748–1756.

(11)  Lianrong Wang, Susu Jiang, Zixin Deng, Peter Dedon, Shi Chen*.  DNA phosphorothioate modification – a new multi-functional epigenetic system in bacteria. FEMS Microbiology Reviews. 2019, 43(2): 109~122 doi.org/10.1093/femsre/fuy036.

(12)  Tong Tong#, Si Chen#, Lianrong Wang#, You Tang#, Jae Yong Ryu, Susu Jiang, Xiaolin Wu, Chao Chen, Jie Luo, Zixin Deng, Zhiqiang Li, Sang Yup Lee*, Shi Chen*. Occurrence, evolution, and functions of DNA phosphorothioate epigenetics in bacteria, Proc Natl Acad Sci U S A, 2018, 2018,115(13):2988-2996. doi:10.1073/pnas.1721916115.  (*corresponding authors) (*co-first author)

(13)  Chao Chen#, Lianrong Wang#, Si Chen, Xiaolin Wu, Meijia Gu, Xi Chen, Susu Jiang, Yunfu Wang Zixin Deng, Peter C. Dedon, Shi Chen*. Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes. Proc Natl Acad Sci U S A, 2017, Apr, doi: 10.1073/pnas.1702450114. (*co-first author)

(14)  Xuan Zou#, Lianrong Wang#, Zhiqiang Li, Jie Luo, Yunfu Wang, Zixin Deng, Shiming Du, Shi Chen*. Genome engineering and modification toward synthetic biology for the production of antibiotics. Medicinal Research Reviews, 2018, Jan, 38(1): 229~260. (#co-first authors)

(15)  Shuangju Wu#, Lianrong Wang#, Rui Gan, Tong Tong, Hao Bian, Zhiqiang Li, Shiming Du, Zixin Deng, Shi Chen*. Signature arsenic detoxification pathways in Halomonas sp. GFAJ-1, mBio, 2018 May 1; 9 (3): e00515-18. doi: 10.1128/mBio.00515-18. 

(16)  Fei Wang#, Lianrong Wang#, Xuan Zou, Suling Duan, Zhiqiang Li, Zixin Deng, Jie Luo, Sang Yup Lee*, Shi Chen*. Advances in CRISPR-Cas systems for RNA targeting, tracking and editing. Biotechnology Advances. 2019, Mar 27. pii: S0734-9750(19)30052-7. doi: 10.1016/j.biotechadv.2019.03.016. (*corresponding authors)

(17)  Qinqin Huang, Yin Wang, Xingxiang Chen, Yimeng Wang, Zhiqiang Li, Shiming Du, Lianrong Wang*, Shi Chen*. Nanotechnology-Based Strategies for Early Cancer Diagnosis Using Circulating Tumor Cells as a Liquid Biopsy. Nanotheranostics, 2018, 2(1): 21-41.

(18)  Jiang D, Zou X, Zhang C, Chen J, Li Z, Wang Y, Deng Z, Wang L*, Chen S*. Gemin5 plays a role in unassembled-U1 snRNA disposal in SMN-deficient cells. FEBS Lett. 2018 Mar 14. 592 (2018) 1400–1411. doi: 10.1002/1873-3468.13031.

(19)  Gan R, Wu X, He W, Liu Z, Wu S, Chen C, Chen S, Xiang Q, Deng Z, Liang D, Chen S*, Wang L*. DNA phosphorothioate modifications influence the global transcriptional response and protect DNA from double-stranded breaks. Scientific Reports. 2014 Oct 16;4:6642. (*corresponding authors)

(20)  He W, Huang T, Tang Y, Liu Y, Wu X, Chen S, Chan W, Wang Y, Liu X, Chen S*, Wang L*. Regulation of DNA phosphorothioate modification in Salmonella enterica by DndB. Scientific Reports. 2015 Jul 20;5:12368. (*corresponding authors)

(21)  Lai C, Wu X, Chen C, Huang T, Xiong X, Wu S, Gu M, Deng Z, Chen X, Chen S*, Wang L*. In vivo mutational characterization of DndE involved in DNA phosphorothioate modification. PLoS One. 2014 Sep 30;9(9):e107981. (*corresponding authors)

(22)  Wang L, Chen S, Xiao X, Huang X, You D, Zhou X, Deng Z. arsRBOCT arsenic resistance system encoded by linear plasmid pHZ227 in Streptomyces sp. Strain FR-008. Applied and Environmental Microbiology. 2006 ;72(5):3738-42.

(23)  Lei Xiong#, Siyi Liu#, Si Chen#, Yao Xiao#, Bochen Zhu, Yali Gao, Yujing Zhang, Beibei Chen, Jie Luo, Zixin Deng, Xiangdong Chen, Lianrong Wang, Shi Chen*. A new type of DNA phosphorothioation-based antiviral 1 system in archaea. Nature Communications, (2019) 10:1688, https://doi.org/10.1038/s41467-019-09390-9.

(24)  Sisi Xia, Jun Chen, Liqiong Liu, Yue Wei, Zixin Deng, Lianrong Wang, Shi Chen*. Tight control of genomic phosphorothioate modification by the ATP-modulated autoregulation and reusability of DndB. Molecular Microbiology, 2019 Apr;111(4):938-950  

(25)  Liqiong Liu, Yizhou Zhang, Dongxu Jiang, Shiming Du, Zixin Deng, Lianrong Wang, and Shi Chen*. Recent Advances in the Genomic Profiling of Bacterial Epigenetic Modifications. Biotechnol. J. 2019, Jan, 14, 1800001. DOI: 10.1002/biot.201800001.

(26)  Ge Yan, Xingxiang Chen, Shiming Du, Zixin Deng, Lianrong Wang, Shi Chen*. Genetic mechanisms of arsenic detoxification and metabolism in bacteria. Current Genetics, (2019) Apr, 65:329–338

(27)  Haotian Chi, Xiaoli Wang, Yue Shao, Ying Qin, Zixin Deng, Lianrong Wang, Shi Chen*. Engineering and modification of microbial chassis for systems and synthetic biology. Synthetic and Systems Biotechnology. Mar, 4 (2019) 25–3326. doi.org/10.1016/j.synbio.2018.12.001.

(28)  Sisi Xia, Jun Chen, Liqiong Liu, Yue Wei, Zixin Deng, Lianrong Wang, Shi Chen*. Tight control of genomic phosphorothioate modification by the ATP-modulated autoregulation and reusability of DndB. Molecular Microbiology, 2019 Apr;111(4):938-950. DOI: 10.1111/mmi.14186.

(29)  You D, Wang L, Yao F, Zhou X, Deng Z. A novel DNA modification by sulfur:DndA is a NifS-like cysteine desulfurase capable of assembling DndC as an iron-sulfur cluster protein in Streptomyces lividans. Biochemistry. 2007 .46(20):6126-33.

(30)  Chen S, Wang L, Deng Z. Twenty years hunting for sulfur in DNA. Protein Cell. 2010,191:14-21.

(31)  Chan W, Chen B, Wang L, Taghizadeh K, Demott MS, Dedon PC. Quantification of the 2-deoxyribonolactone and nucleoside 5’-aldehyde products of 2-deoxyribose oxidation in DNA and cells by isotope-dilution gas chromatography mass spectrometry: differential effects of gamma-radiation and Fe2+-EDTA. J Am Chem Soc.2010, 132(17):6145-53.

(32)  Ding C, Wu Z, Huang L, Wang Y, Xue J, Chen S, Deng Z, Wang L, Song Z, Chen S. Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure. Scientific Reports. 2015 Nov 4;5:16064.

(33)  Xu T, Liang J, Chen S, Wang L, He X, You D, Wang Z, Li A, Xu Z, Zhou X, Deng Z. DNA phosphorothioation in Streptomyces lividans:mutational analysis of the dnd locus. BMC Microbiology, 2009, 9:41.

(34)  Chen S, Mao X, Shen Y, Zhou Y, Li J, Wang L, Tao X, Yang L, Wang Y, Zhou X, Deng Z, Wei D. Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis. Applied and Environmental Microbiology, 2009 ,75(6):1778-81.